Исследование показывает первый шаг к разработке теста для измерения статуса витамина D в образцах волос.
Более 1 миллиарда человек во всем мире испытывают дефицит Витамин D. This deficiency affects primarily bone health and also increases one’s risk of cardiovascular болезнь, диабет, Онкология etc. Due to this implication assessment of Витамин D has gained interest. Добавки Витамина Д измеряется через анализ крови which measures the concentration of best biomarker of Витамин Д в кровь называемый 25-гидроксивитамин D (25(OH)D3). кровь sample needs to be collected in hygienic conditions under trained medical personnel. This test is an accurate estimate but its biggest limitation is that it reflects status of Витамин D at a single time point and does not account for high variability of Витамин D thus requires frequent sampling. A single value may not be an ideal representation as Добавки Витамина Д levels could differ in our body depending upon season or other factors. The test is expensive and a cost burden especially in low-and-middle-income countries. But, because high proportion of population is now deficient in Витамин D this кровь тест становится все более востребованным.
Исследование, опубликованное в Питательные вещества led by Trinity College, Dublin has shown for the first time that Витамин D can be extracted and measured from human hair1. Authors themselves provided three hair samples for the study, two harvested from crown area of the scalp and one from beard, which were cut into 1cm length, weighed, washed and dried. 25(OH)D3 was extracted from these samples using the same procedure used to extract steroid hormones from hair2 in which a mathematical formula takes measured concentrations of the biomarker using Liquid chromatography-Mass Spectrometry (LC-MS) or Mass Spectrometry (MS) and provides an approximation of concentration in the hair. At the same time, кровь из всех образцов тканей также анализировали с помощью МС. Были измерены поддающиеся количественной оценке концентрации 25(OH)D3, присутствующие в образцах волос и бороды, что подтвердило осуществимость такого измерения.
Human hair grows approximately 1 cm every month and Витамин D is deposited to the hair continuously. More Витамин D is deposited to hair when levels of Витамин D в кровь are high and less is deposited when they are low. A test which could measure витамин levels from hair can tell us about Vitamin D status over a longer duration – several months at least taking into account seasonal differences. The longer one’s hair, more accurately status of Vitamin D can be measured, example several months to years and this could be treated as a long-term record.
This is an inexpensive, non-invasive method to capture Витамин D status and can help medical professionals to maintain levels of Vitamin D concentrations in a person over time. The exact association between Vitamin D in кровь and in hair over a period of time needs further research as factors such as hair color, hair thickness and texture could affect Витамин D in hair.
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Источник (ы)
1. Zgaga L et al. 2019. Измерение 25-гидроксивитамина D в человеческих волосах: результаты исследования Proof-of-Concept. Питательные вещества. . 11 (2). http://dx.doi.org/10.3390/nu11020423
2. Gao W et al. 2016. Анализ эндогенных стероидных гормонов в человеческих волосах на основе ЖХ-МС. J. Steroid Biochem. Мол. Биол. 162. https://doi.org/10.1016/j.jsbmb.2015.12.022
